Heterologous regeneration is achieved through the injection or application of synthetic substances—whether produced in a laboratory or, for example, derived from plants.

Hyaluronic acid: There are certain types of hyaluronic acid, known as low-molecular-weight hyaluronic acid, that may potentially offer benefits. Unfortunately, this has not yet been scientifically proven except in a few cases.

Polynucleotides: The same applies as for hyaluronic acid.

Plant-derived exosomes: These are currently all the rage and show interesting potential as topical treatments, such as in premium ointments; however, their introduction into tissues via needle injection is prohibited.