Lichen sclerosus is an inflammatory disease, and like all inflamed tissues, it does not respond well to factors that further increase inflammation.

• CO₂ and erbium lasers are rarely recommended because they promote regeneration through the inflammatory process.
• Lasers, on the other hand, can be very useful for vaginal tissue regeneration; since the vagina is in contact with the vulva, it must be in the best possible condition.
• Radiofrequency treatment must be carefully evaluated because it induces the production of hard, inelastic collagen.
• LEDs (lights of a specific wavelength that have been used by dermatologists for many years for skin care) can be very useful for reducing inflammation.
• Shock waves induce tissue regeneration and soften tissues; they are a promising method that must be validated by high-quality scientific studies.
• Transdermal and transmucosal delivery are methods that facilitate the penetration of topical products through weak electrical currents or microchannels, which are created using radiofrequency or laser techniques.

The treatment of autoimmune diseases, intestinal and digestive disorders, and psychological conditions is essential for the proper and effective management of patients suffering from lichen sclerosus.